The World's Oldest Virgin

According to Wikipedia, "By the late 1960s, the sexual revolution of the baby boomer generation had refocused public attitudes about sex. Times changed, but Day's films did not. Day's next film Do Not Disturb (1965) was popular with audiences, but her popularity soon waned. Critics and comics dubbed Day 'The World's Oldest Virgin', and audiences began to shy away from her films. As a result, she slipped from the list of top box–office stars, last appearing in the top ten with the hit film The Glass Bottom Boat (1966). One of the roles she turned down was that of Mrs. Robinson in The Graduate, a role that eventually went to Anne Bancroft. In her published memoirs, Day said she had rejected the part on moral grounds: she found the script 'vulgar and offensive'."

It was in 1965 that the American pianist, composer and wit Oscar Levant wrote in his own memoir, "My last picture for Warners was Romance on the High Seas. It was Doris Day's first picture; that was before she became a virgin." This quote (invariably paraphrased) is often misattributed to Groucho Marx.